Blast-induced phenotypic switching in cerebral vasospasm
نویسندگان
چکیده
منابع مشابه
Blast-induced phenotypic switching in cerebral vasospasm.
Vasospasm of the cerebrovasculature is a common manifestation of blast-induced traumatic brain injury (bTBI) reported among combat casualties in the conflicts in Afghanistan and Iraq. Cerebral vasospasm occurs more frequently, and with earlier onset, in bTBI patients than in patients with other TBI injury modes, such as blunt force trauma. Though vasospasm is usually associated with the presenc...
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There are essentially two principal end points in cerebrosvascular regulation: maintenance of an adequate supply of blood and energy-yielding substra tes to the brain, despite the imposition of physiological or pathological stresses such as hypoxemia or reduced perfusion pressure, and precise and rapid coupling of regional cerebral bload flow (CBF) to changes in neuronal r equ i r emen t s 3 2 ...
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All forms of cerebral inflammation as found in bacterial meningitis, cerebral malaria, brain injury, and subarachnoid haemorrhage have been associated with vasospasm of cerebral arteries and arterioles. Vasospasm has been associated with permanent neurological deficits and death in subarachnoid haemorrhage and bacterial meningitis. Increased levels of interleukin-1 may be involved in vasospasm ...
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Cerebral arteries have an abundant supply of adrenergic nerve fibers which are believed to release vasoactive substances responsible for the induction of cerebral vasospasm. To assess the importance of adrenergic nerves in this phenomenon, high doses (600 microgram/ml) of 6-hydroxydopamine (6-OHDA) were used to produce in vitro chemical sympathectomy in bovine middle cerebral artery. 6-OHDA red...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2011
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1105860108